The characterization of peptides and proteins can be challenging due to issues such as adsorption, varying hydrophobicities, and specificity to name just a few. When analyzing peptides by Liquid Chromatography (LC) and Mass Spectrometry (MS),… Read more >
What does “intelligence” mean in the context of biopharma analysis? Given the complex setting, much of the answer comes down to the task a user needs to complete, along with the question of who exactly… Read more >
There are two primary multi-attribute monitoring (MAM) assay choices for biologic development and QC: subunit protein mass analysis and peptide mapping by LC-MS. Here we explore how peptide mapping LC-MS MAM workflows are being used.
Two MAM approaches for biotherapeutic analysis are being implemented today; one focused on the analysis of monoclonal antibody (mAb) subunits, and the other focused on the analysis of peptides from a protein digest (peptide mapping workflow). Both have their advantages and disadvantages. Here, we explore MAM for mAb subunit analysis.
Q&A time: What is acrylamide? How dangerous is it? How do food testing laboratories detect it?
The improvements in LC-MS technology under GxP compliant-ready informatics for biopharmaceutical analysis has prepared the industry to expand the role of MS technologies beyond product characterization toward monitoring product and process quality attributes.
Where does your service engineer turn if they need help? Meet Dipesh. He works in Waters’ Global Service Support (GSS) department in Wilmslow, UK. The team supports field service engineers, writes supporting documentation, and advises on service requirements for new products.
Meet Vicky, who joined Waters’ Customer Success Team about two years ago with 20 years of LC-MS experience. She specializes in clinical forensic and toxicological applications supporting customers in Northern Europe.
Meet Ian, an LC-MS system engineer based in the UK, who is responsible for system installs, service, and maintenance. Being a former Waters customer drives Ian’s approach to customer service and going the extra mile.
Labs like King’s Liver Laboratories in London need to analyze thousands of samples with fast turnaround times, so it’s critical to have reliable LC-MS/MS instrumentation that works every day and provides accurate and precise results.