Waters’ new ACQUITY PREMIER Solution is designed to reduce variability associated with metal-sensitive analytes and eliminate time-consuming tasks like LC system and column passivation.
After another wrong assignment, I knew there had to be a better way to improve my database matching! Spectral library matching is an integral component in the workflow of untargeted, or high resolution mass spectrometry,… Read more >
Why do we lose compounds while trying to measure them? Are they disappearing? Are they breaking down? Why and how? It all starts with adsorption and for certain metal-sensitive analytes, it renders chromatographic analysis using… Read more >
Late nights in the laboratory seem to be the only thing I can really count on when I am trying to get reproducible chromatography for certain compounds. But what I really want, is to go… Read more >
Retaining polar analytes using reversed phase (RP) chromatographic conditions have long frustrated scientists. Trying to promote interactions between polar analytes and a non-polar reversed phase surfaces can often bring the most experienced separation scientist to… Read more >
Many years ago, I was hired by a biopharma company to develop analytical methods for therapeutic oligonucleotides. When a new colleague warned me about sample loss on LC columns I looked at him with skepticism.… Read more >