Columns - Blogging About What's Possible

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Arc Premier Solution Improves Data Quality for Challenging Compounds

By June 15, 2021
analyte

Waters Arc Premier Solution is optimized with MaxPeak HPS Technology and developed for use with 2.5 µm MaxPeak HPS Columns to deliver improvements in separation and detection of metal-sensitive analytes.

Categories: Columns, Innovation, MaxPeak Premier Solutions, Technologies
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The Quest for Maximum LC Performance: A Well-Packed Column Bed

By April 26, 2021
packed column

As chromatographers seek maximum separation performance on their liquid chromatography (LC) systems, a key factor is the use of LC columns with an optimally packed column bed density. Solid-core columns manufactured with strict quality control… Read more >

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New ACQUITY Premier Solution Reduces Variability for Metal-Sensitive Analytes

By February 10, 2021
ACUITY PREMIER

Waters’ new ACQUITY Premier Solution is designed to reduce variability associated with metal-sensitive analytes and eliminate time-consuming tasks like LC system and column passivation.

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Waters ACQUITY Premier Columns: A New Solution for Sample Loss of Metal-Sensitive Analytes

By October 14, 2020

Why do we lose compounds while trying to measure them? Are they disappearing? Are they breaking down? Why and how? It all starts with adsorption and for certain metal-sensitive analytes, it renders chromatographic analysis using… Read more >

Categories: Columns, MaxPeak Premier Solutions, Technologies
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Late Night’s in the Laboratory

By October 11, 2020

Late nights in the laboratory seem to be the only thing I can really count on when I am trying to get reproducible chromatography for certain compounds. But what I really want, is to go… Read more >

Categories: Columns, MaxPeak Premier Solutions, Technologies

In Need of Some Reversed Phase Polar Acid Relief

By October 1, 2020

Retaining polar analytes using reversed phase (RP) chromatographic conditions have long frustrated scientists.  Trying to promote interactions between polar analytes and a non-polar reversed phase surfaces can often bring the most experienced separation scientist to… Read more >

Categories: Columns, MaxPeak Premier Solutions, Technologies

Addressing the Mystery of Sample Loss

By September 24, 2020

Many years ago, I was hired by a biopharma company to develop analytical methods for therapeutic oligonucleotides. When a new colleague warned me about sample loss on LC columns I looked at him with skepticism.… Read more >

Categories: Columns, MaxPeak Premier Solutions
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Bringing the Future Into Focus with Waters’ Virtual Events

By August 25, 2020

In the midst of the COVID-19 pandemic the power of technology has emerged center stage, keeping the industry connected at a time when many ordinary avenues of communication have been cut off over safety concerns.… Read more >

Categories: Automation, Chemical, Columns, COVID-19, Food & Environmental, Leadership, Pharmaceutical, Technologies

When Resolving Minor Differences in Protein Therapeutics Can Have a Major Impact

By November 6, 2018

Scientists from Waters and Pfizer collaborated to take on the challenge of engineering a novel reversed-phase LC column for high-throughput separations with enhanced resolution, selectivity, and recovery of target mAbs and ADCs.

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I Resolve to Get Better mAb Separations

By August 8, 2018

We listened and learned how scientists separate mAbs and ADCs; then we designed a novel column for LC-MS bioseparations A critical step toward the prolific and successful use of monoclonal antibodies (mAb) as biotherapeutics occurred… Read more >

Categories: Columns
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