Recent posts

Waters ACQUITY PREMIER Columns: A New Solution for Sample Loss of Metal-sensitive Analytes

By October 14, 2020

Why do we lose compounds while trying to measure them? Are they disappearing? Are they breaking down? Why and how? It all starts with adsorption and for certain metal-sensitive analytes, it renders chromatographic analysis using… Read more >

Categories: Columns, PREMIER Blog Series, Technologies
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Late Night’s in the Laboratory

By October 11, 2020

Late nights in the laboratory seem to be the only thing I can really count on when I am trying to get reproducible chromatography for certain compounds. But what I really want, is to go… Read more >

Categories: Columns, PREMIER Blog Series, Technologies

In Need of Some Reversed Phase Polar Acid Relief

By October 1, 2020

Retaining polar analytes using reversed phase (RP) chromatographic conditions have long frustrated scientists.  Trying to promote interactions between polar analytes and a non-polar reversed phase surfaces can often bring the most experienced separation scientist to… Read more >

Categories: Columns, PREMIER Blog Series, Technologies

Addressing the Mystery of Sample Loss

By September 24, 2020

Many years ago, I was hired by a biopharma company to develop analytical methods for therapeutic oligonucleotides. When a new colleague warned me about sample loss on LC columns I looked at him with skepticism.… Read more >

Categories: Columns, PREMIER Blog Series
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Bringing the Future Into Focus with Waters’ Virtual Events

By August 25, 2020

In the midst of the COVID-19 pandemic the power of technology has emerged center stage, keeping the industry connected at a time when many ordinary avenues of communication have been cut off over safety concerns.… Read more >

Categories: Automation, Chemical, Columns, COVID-19, Food & Environmental, Leadership, Pharmaceutical, Technologies

When Resolving Minor Differences in Protein Therapeutics Can Have a Major Impact

By November 6, 2018

Scientists from Waters and Pfizer collaborated to take on the challenge of engineering a novel reversed-phase LC column for high-throughput separations with enhanced resolution, selectivity, and recovery of target mAbs and ADCs.

Categories: Columns, Technologies
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I Resolve to Get Better mAb Separations

By August 8, 2018

We listened and learned how scientists separate mAbs and ADCs; then we designed a novel column for LC-MS bioseparations A critical step toward the prolific and successful use of monoclonal antibodies (mAb) as biotherapeutics occurred… Read more >

Categories: Columns
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Setting a New Standard for Reserved-Phase Separations of Monoclonal Antibodies and Antibody Drug Conjugates

By May 15, 2018

A new approach to stationary phase chemistry for reversed-phase LC analysis of proteins, including monoclonal antibodies and antibody drug conjugates, delivers higher fidelity data especially for MS-based peak identification.

Categories: Columns
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Maximizing LC Column Lifetime: 3 Tips to Reduce Physical Deterioration

By September 8, 2017

Three tips to help you reduce physical contaminants from impacting your chromatographic column’s longevity.

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Infographic: What’s the Best Column for Polar Compound Retention?

By August 3, 2017
T3 for polar compound retention

Retaining and separating highly polar, water-soluble organic compounds has been a challenge for separations scientists who prefer reversed-phase chromatography as their technique of choice. See how Waters has addressed these analytical challenges with our T3 columns.

Categories: Columns
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