Recent posts

How to improve analytical method transfers for biotherapeutics

By May 21, 2018

“Assuming continuous improvement is a worthy goal, there is every reason to improve validated chromatographic methods if you’re working with the right instrument technology,” says Eric Grumbach of Waters. See what that means for developing and transferring methods for biologic drugs.

Categories: Pharmaceutical, Technologies
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Infographic: What’s the Best Column for Polar Compound Retention?

By August 3, 2017
T3 for polar compound retention

Retaining and separating highly polar, water-soluble organic compounds has been a challenge for separations scientists who prefer reversed-phase chromatography as their technique of choice. See how Waters has addressed these analytical challenges with our T3 columns.

Categories: Columns
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New Preparative Chromatography Learning Tool: Purification Primer

By May 11, 2017

Chromatographers sometimes find themselves challenged as they move from analytical to preparative scales. To help gain a higher-level of understanding and knowledge of purification, check out our primer.

Categories: Technologies
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Changing the Rules with Mass Detection

By February 13, 2017

With access to multiple mass spectrometry systems of varying degrees of sophistication, Davy Guillarme (University of Geneva, Switzerland) wasn’t actively looking for new mass detection solutions. Nevertheless, the Waters ACQUITY QDa mass detector caught his eye.

Categories: Technologies
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High-throughput Microscale Bioanalysis is not a Paradox

By May 21, 2016

  Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in… Read more >

Categories: Pharmaceutical, Technologies
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Tof-HRMS: Rescuing Low-Exposure Bioanalysis Applications from Chemical Noise

By April 18, 2016

The drug development process requires pharmacokinetic (PK) analysis to be performed as part of safety and efficacy studies in both preclinical species and human subjects. For high-sensitivity bioanalysis, liquid chromatography (LC) coupled to a triple… Read more >

Categories: Chemical, General, Pharmaceutical, Technologies
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Three Reasons for Biopharmaceutical Labs to Add Mass Detection to Routine Analyses

By March 9, 2016

As regulators focus in on the critical quality attributes of biotherapeutics, what can biopharmaceutical labs in late development or QC do to increase confidence in their bioseparations – other than to run more assays?

Categories: Pharmaceutical, Technologies
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It’s time to nominate a peer for the New Investigator’s Award!!

By February 19, 2016

Recently, Bioanalysis Zone announced that nominations are now being accepted for the New Investigator’s award (formerly the Young Investigators award) which is sponsored by Waters Corporation for the 5th year in a row. This is… Read more >

Categories: General, Pharmaceutical, Technologies
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Attention Method Development Scientists! Learn about novel tools for replicating your existing methods

By November 18, 2015

Webinar Highlights | Simplifying Methods Transfer: Novel Tools for Replicating Your Established Methods on an ACQUITY Arc System I’m Dr. Paula Hong, Principal Scientist at Waters Corporation. I recently conducted a webinar that talked about the… Read more >

Categories: Technologies
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Chapter and Verse: USP 621 and You

By February 23, 2015

In August 2014, the United States Pharmacopeia and the National Formulary (USP-NF) put into effect new guidelines to “allowable adjustments” in its Chapter <621> (USP37-NF32 S1). And as of August 1, 2016 when USP 39… Read more >

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