Q&A from a recent forensic toxicology webinar on using an ACQUITY UPLC I-Class/Xevo TQ-S micro MS system for quantifying cannabinoids in oral fluid.
Two MAM approaches for biotherapeutic analysis are being implemented today; one focused on the analysis of monoclonal antibody (mAb) subunits, and the other focused on the analysis of peptides from a protein digest (peptide mapping workflow). Both have their advantages and disadvantages. Here, we explore MAM for mAb subunit analysis.
#71: Learn how Empower CDS calculates Detector Noise and Drift using the System Suitability option.
#70. Using the System Suitability Option, learn how Empower Software calculates Baseline Noise and Drift. This can be useful if you are not in a regulated laboratory environment when you probably want to calculate Signal to Noise without the USP, EP, or JP formula.
We discuss analytical options using LC and GC with MS/MS to detect the pesticide fipronil in eggs for food safety testing.
“Assuming continuous improvement is a worthy goal, there is every reason to improve validated chromatographic methods if you’re working with the right instrument technology,” says Eric Grumbach of Waters. See what that means for developing and transferring methods for biologic drugs.
#69: Learn how Empower Software calculates Peak-to-Peak Noise for USP, EP, and JP Signal-to-Noise calculations.
A new approach to stationary phase chemistry for reversed-phase LC analysis of proteins, including monoclonal antibodies and antibody drug conjugates, delivers higher fidelity data especially for MS-based peak identification.
Considerations for optimizing trapping conditions, such as flow rate and trapping volume, in nanoscale and microflow LC-MS.
We begin a multi-part discussion about the System Suitability option in Empower Software, starting with what are Statistical Moments and how are they helpful.