Recent posts

Binary vs. Quaternary Pumps: High Pressure Mixing vs. Low Pressure Mixing

By June 27, 2016

Welcome to the next installment in my series on binary vs. quaternary pumps for liquid chromatography! In my previous post, I discussed how gradients are created as well as the importance of having accuracy and precision… Read more >

Categories: Technologies
Tags: ,

Binary vs. Quaternary Gradients: Precision vs. Accuracy

By June 20, 2016

In the last blog post I talked about how a gradient is formed by the two different pumps.  Today, we will look at the ability for those pumps to deliver the actual gradient that a… Read more >

Categories: Technologies
Tags: , ,

Binary vs Quaternary Pumps: How is a Gradient Created?

By June 13, 2016

How is a Gradient Created? Any liquid chromatograph (LC) is an amalgamation of a certain set of components that delivers to the scientist a monograph of the sample they are analyzing.  Traditionally, an LC system… Read more >

Categories: Technologies

Has Your Dinner Menu Been Quantified?

By May 26, 2016

For decades, food security was viewed exclusively through the lens of shortages. In the 1960s, when daily food availability in emerging countries was just 1,850 kcal per person as many as half of the world’s… Read more >

Categories: Food & Environmental, Technologies
Tags: , , , , , ,

Pumping Ions – An Exercise in Engineering Sensitivity Into the Xevo TQ-XS Mass Spectrometer

By May 24, 2016

The challenge: Create the most sensitive mass spectrometer for quantitative analysis. That’s a tall order for any design engineering team. When given that assignment for a next-generation, tandem quadrupole mass spectrometer, our design engineers first… Read more >

Categories: Technologies
Tags: , ,

High-throughput Microscale Bioanalysis is not a Paradox

By May 21, 2016

  Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in… Read more >

Categories: Pharmaceutical, Technologies
Tags: , , , , , , ,

Tandem Quad Mass Spectrometry: The Foundation of Product Safety, Efficacy, and Decision-making

By May 17, 2016

There is a rightfully high expectation from consumers that the amounts of compounds and ingredients that producers report in their goods are accurate down to trace levels.  Whether personally or professionally, we all rely on… Read more >

Categories: Technologies
Tags: , , , , , ,

What’s the big deal about ion mobility mass spectrometry?

By April 29, 2016

Ion mobility spectrometry (IMS) is a technique that differentiates ions based on their size, shape, charge, and mass. While often used in small, portable devices at airports and remote locations for rapidly detecting small molecules… Read more >

Categories: Technologies
Tags: , , ,

Tof-HRMS: Rescuing Low-Exposure Bioanalysis Applications from Chemical Noise

By April 18, 2016

The drug development process requires pharmacokinetic (PK) analysis to be performed as part of safety and efficacy studies in both preclinical species and human subjects. For high-sensitivity bioanalysis, liquid chromatography (LC) coupled to a triple… Read more >

Categories: Pharmaceutical, Technologies
Tags: , , , , , , , , , , ,

Mass detection and mAb QC: How a cost-effective and robust peptide mapping method confirms CDR peptides – and can be validated

By March 15, 2016

The quality issues of biopharmaceutical therapeutics are definitely different from chemical drugs because of the increased complexity of manufacturing processes and complexity of the biologic molecules themselves. There is an increasing need for detailed product… Read more >

Categories: Pharmaceutical, Technologies
Tags: , , , , ,