Scientists from Waters and Pfizer collaborated to take on the challenge of engineering a novel reversed-phase LC column for high-throughput separations with enhanced resolution, selectivity, and recovery of target mAbs and ADCs.
When considering that the range of compounds that might be subject to chromatography goes from highly volatile species with molecular weights of tens of Daltons, to proteins with molecular weights of hundreds of thousands of Daltons, maybe it isn’t so surprising that there are a variety of separation techniques required.
Considerations for optimizing trapping conditions, such as flow rate and trapping volume, in nanoscale and microflow LC-MS.
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One scientist at a major global pharma company estimated that an analytical method could see up to 100 transfers in its lifetime. Increasingly, such transfers will take place across geographic borders. How ready are you to mobilize your methods?
On the impact of retentivity and characteristics of the stationary phases for reversed-phase proteomic separations and how you can use them to your advantage.
Can pairing column stationary phases improve nanoflow and microflow LC-MS results? Let’s take a closer look at the basics of trapping and the advantages and considerations for implementing a trapping step in a LC separation in part 1 of this 3-part series.
Is your analytical method bound for the lab down the hall, or the lab halfway around the world? If you’re an analytical or QC scientist, get ready for more method transfers between organizations. We explore the complexities of analytical method transfer in part 2 of our ongoing series.
There’s a new analytical testing landscape taking shape, and it’s having a big effect on how we develop, transfer, and update methods. Data quality and business efficiency are both at stake. Are you ready?
VP Joe Biden inspires proteomics scientists with a reminder of ‘the urgency of now’ for cancer researchers The 2017 edition of the Human Proteome Organization (HUPO) World Congress came to a successful conclusion this fall,… Read more >