Recent posts

Waters and BioanalysisZone are Highlighting our Bioanalytical Chemists

By September 26, 2016

Like the black panther, are analytical scientists going extinct? In a presidential election year, we are reminded of the many tough choices we face—Democrats or Republicans, plastic or paper, ketchup or mustard, soccer or football.… Read more >

Categories: Pharmaceutical
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Is using Microflow LC in an Industrial Setting Really that Cumbersome?

By August 30, 2016

Microflow or nanoflow chromatography has been used mostly in the academic and fundamental research environment in the past for its various advantages over analytical liquid chromatography, but rarely in the industrial settings. This is most… Read more >

Categories: Pharmaceutical, Technologies
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What Bioanalysis Zone’s New Investigator Award Says About the Future of Science: An Interview with Erin Chambers, PhD

By August 15, 2016

Dr. Erin Chambers is a Director in the Scientific Operations group at Waters Corporation. She recently served as a judge for the Bioanalysis Zone New Investigator Award. I sat down with Erin to gauge her… Read more >

Categories: Pharmaceutical
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Microflow LC Offers Better Sensitivity Due to Reduced Matrix Effects!

By August 15, 2016

What are matrix effects? In my last post, “What is Microflow,”  I talked about two main parameters – better sampling efficiency and reduced matrix effects – for microflow LC/MS that result in higher sensitivity than its… Read more >

Categories: Pharmaceutical, Technologies
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In Beverly, the Shoe Fits for Bioanalysis!

By July 20, 2016

This past May, many of the nation’s leading bioanalysts gathered in New England to share ideas and explore the latest advances in mass spectrometry, liquid chromatography, and sample preparation for large molecule quantification. At Waters’… Read more >

Categories: Pharmaceutical
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Oligonucleotide Therapeutics on the Rise… Again

By July 7, 2016

Oligonucleotide drug development has seen its share of ups and downs over the past 20 years – but why? The promise of antisense oligonucleotides (ASOs) and later small interfering oligonucleotides (siRNAs) as therapeutics that can… Read more >

Categories: Pharmaceutical
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Phenome Research Footprint Continues to Expand

By June 8, 2016

Congratulations are in order as the University of Birmingham is the most recent university to expand the footprint of metabolic phenotyping research centres around the world. As state-of-the-art metabolic phenotyping facilities able to conduct small-scale… Read more >

Categories: Pharmaceutical

An Inflection Point for Biopharmaceutical Host Cell Protein Analysis

By June 7, 2016

Has LC-MS Become a Generally Accepted Tool for Complementing Immunoassay-based HCP Analysis? My colleague Catalin Doneanu and I just returned from Lisbon, Portugal, where we attended the BEBPA Conference on Host Cell Protein (HCP) analysis.… Read more >

Categories: Pharmaceutical

Webinar Highlights: Facilitating Drug Discovery with HDX-Mass Spectrometry

By May 23, 2016

Genetic Engineering and Biotechnology News and Waters recently conducted a webinar on how hydrogen deuterium exchange mass spectrometry (HDX-MS) can improve biotherapeutic drug discovery and development processes. Our first speaker, Prof. Ganesh Anand — a… Read more >

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High-throughput Microscale Bioanalysis is not a Paradox

By May 21, 2016

  Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in… Read more >

Categories: Pharmaceutical, Technologies
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