Let’s look at the area of organ transplantation as an example of how the TDM field is developing. We look at the progression from immunoassays to LC-MS assays.
Therapeutic drug monitoring (TDM) is a multi-disciplinary clinical specialty, aimed at improving patient care by monitoring drug concentration levels in blood. It enables adjustment of drug dosage for individuals to improve patient outcomes.
Targeted LC-MS based assays are increasingly applied in the post-discovery Omics area with an emphasis on validation, the first of many phases in translational research; and in studies that are aimed at gaining the understanding… Read more >
The world is facing an unprecedented convergence of environmental and lifestyle factors that dramatically increase our risk of chronic disease. Global warming, antimicrobial resistance, aging populations, and the prevalence of lifestyle-related illnesses are systematically affecting… Read more >
The spatial distribution of molecular species in a sample can provide a wealth of information about biological, chemical and physiological processes. Mass spectrometry (MS) imaging is a rapidly developing research technique that enables specific measurement… Read more >
In biomedical research, scientists need the ability to accurately and precisely measure a biomarker or set of biomarkers in some disease vs. healthy experimental design. The ability to measure something depends on the ability of… Read more >
“Fast is fine; but accuracy is everything.” The quote is attributed to the famous Wyatt Earp, a sharpshooter and lawman who, with help from his two brothers, sent three outlaws to their graves in the… Read more >
How does mass spectrometry (MS) imaging provide a molecular image that can be used for the biochemical characterization of histological images? A rapidly developing technique for clinical research, MS imaging enables investigation of the spatial… Read more >
According to published reports by Hiscox UK in 2008, just listening to the sound of a sports car increased salivary testosterone levels in male and female participants. Another study, by Gad Saad et al, measured… Read more >
U.S. FDA Prepares to Oversee LDTs Recently, the U.S. Food and Drug Administration’s Office of Public Health Strategy and Analysis issued an interesting (and much anticipated) report regarding Laboratory Developed Tests (LDTs). The Agency has… Read more >