Can pairing column stationary phases improve nanoflow and microflow LC-MS results? Let’s take a closer look at the basics of trapping and the advantages and considerations for implementing a trapping step in a LC separation in part 1 of this 3-part series.
#61: Learn how to derive a channel for Timed Mass for 3D MS data in Empower Software. Timed Mass creates a channel that specifies a mass at specified starting times, which can maximize sensitivity and allow us to perform quantification for all components regardless of the differences in mass.
Is your analytical method bound for the lab down the hall, or the lab halfway around the world? If you’re an analytical or QC scientist, get ready for more method transfers between organizations. We explore the complexities of analytical method transfer in part 2 of our ongoing series.
#60. Another option for Deriving Channels in Empower when working with 3D MS data is Total Plot, a 2D chromatogram that plots the sum of all ion intensities acquired across a specified mass range at every time point. It is a subset of the TIC plot, which we covered in Tip 57.
#59: We previously discussed MaxPlot for 3D PDA data in Tip 52. Today we are going to learn about MaxPlot for 3D MS data. MaxPlot is a 2D chromatogram that plots each time point at the maximum intensity across the mass range.
To get the most out of recent innovations in biopharma development and QC such as multi-attribute monitoring, it’s time to better connect the systems that manage biopharma data. This series explores the what, the why, and the how of better biopharma data.
#58: In this tip, we will continue the discussion on deriving a total ion chromatogram (TIC) plot from 3D MS data; specifically, how to improve a noisy TIC plot.
There’s a new analytical testing landscape taking shape, and it’s having a big effect on how we develop, transfer, and update methods. Data quality and business efficiency are both at stake. Are you ready?
#57: How to derive a channel in Empower Software when working with 3D mass spec (MS) data, or the Total Ion Chromatogram (TIC), which plots the sum of all ion intensities acquired across the mass range at every time point.
#56: If you have an ACQUITY QDa Mass Detector on your HPLC or UPLC instrument and collect 3D MS data, there are a number of options for deriving a channel. In today’s tip, we’ll discuss deriving Single Mass from 3D MS data.